Imagine you're the parent of a toddler with a life threatening peanut allergy. Imagine your concern, anxiousness and daily vigilance as you try to keep your child safe. Now imagine there was a therapy that helped desensitize your peanut-allergic little one so that an encounter with a peanut wasn’t fatal. We might not have to imagine much longer. Sublingual immunotherapy (SLIT) has been referred to as “super promising” by Dr. Edwin Kim, an assistant professor of allergy and immunology at the University of North Carolina at Chapel Hill and the study’s lead author.
In a small study, sublingual immunotherapy (SLIT) was effective in desensitizing peanut-allergic toddlers, allowing 74 percent to consume 4,443 milligrams of peanut (about 15 peanuts) without reacting, new research finds.
“What we are seeing is super-promising,” says lead study author Dr. Edwin Kim, an assistant professor of allergy and immunology at the University of North Carolina at Chapel Hill. “We observed significant desensitization in toddlers with peanut allergy,” he told Allergic Living.
What if the “cure” for some autoimmune allergies like asthma and life threatening anaphylaxis could be found in our own bodies? That is what researchers from the Australian National University (ANU) may have discovered in the protein called neuritin. The role of this natural protein plays in the brain and nervous system has been known for years but five years ago researchers began to look at the role it may play in the immune system. The results are promising and researchers hope that they may be the basis for new treatments.
Researchers have discovered a function in the immune system that could hold the key to treating allergic conditions like asthma and stop life-threatening anaphylaxis.
Experts from The Australian National University (ANU) have unearthed a natural way the body prevents autoimmune disease and allergies. The process is driven by a protein in the body called neuritin.
“We found this absolutely fascinating mechanism of our own bodies that stops the production of rogue antibodies that can cause either autoimmunity or allergies,” senior author, ANU Professor Carola Vinuesa, said.
"It’s been known for years that neuritin has a role in the brain and in the nervous system but we found an abundance of neuritin in the immune system and its mechanism – which has never been described in biology.
A new study being presented at the 2021 AAAAI Virtual Annual Meeting, taking place February 26 – March 1, examines the clinical and immunologic features of patients who have sensitivity to sunflower seeds.
A new case series looking at patients who have positive sunflower seed-specific IgE will be introduced during the 2021 American Academy of Allergy, Asthma & Immunology (AAAAI) Virtual Annual Meeting. While the abstract of this research was included in an online supplement to The Journal of Allergy and Clinical Immunology that was published February 1, the full poster (#299) will be presented at the 2021 AAAAI Virtual Annual Meeting.
The retrospective case series examined 117 adult patients sensitive to sunflower seeds. These patients underwent skin tests and detection of specific IgE. At times, oral food challenges were also recommended and performed. A total of 28 patients were recognized to have a clinical allergy to sunflower seed, amounting to 24% of those included in the study. Most of those also had a history of atopic disease and reactions to nuts and Rosaceae fruit. Fourteen patients (50%) suffered anaphylaxis, with all of those reactions graded as moderate save one. Of those suffering from anaphylaxis, 71% needed to go to the emergency department.
As corona virus vaccines start becoming more available, getting everyone vaccinated is of vital importance. In our interview with Dr. James Baker, the former CEO and CMO of Food Allergy Research and Education (FARE), Dr. Baker addresses many concerns within the allergy community. Reporter Kristen Steward and the doctor discuss the effectiveness, safety AND necessity of everyone being vaccinated.
Looking at his bio it sure looks like Dr. James Baker has done it all. He has worked in the government and academia, in small pharma and big pharma. He also spent five years as the CEO and CMO of Food Allergy Research and Education (FARE). Yet when I told him he'd done an amazing amount of work he modestly answered, "I guess that’s how it appears when you get old."
This same combination of humility and sense of humor is apparent in his brief self-description at the bottom of his posts on Pandemic Pondering: A Daily Blog, the website he began when COVID-19 hit last March — immunologist, former Army MD, former head of allergy and clinical immunology at University of Michigan, vaccine developer and opinionated guy. It takes navigating to the site's About page to find out he has published more than 300 peer-reviewed publications, is an inventor on 50 patents, has founded four companies and had many other accomplishments that are too numerous to list.
Throughout 2020 the corona virus pandemic has been global in its impact. The arrival of a COVID-19 Vaccine has brought relief, hope and questions. Is the vaccine safe? In a very few cases individuals that received the vaccine had an anaphylactic reaction. Were these cases isolated incidents? Were there other types of reactions? Did these individuals have a history of anaphylactic reactions? The Centers for Disease Control (CDC) recently published a study of anaphylactic reactions that occurred during December 14–23, 2020 showing that such reactions are exceedingly rare.
Important note:This article is intended for those who understand vaccines as critical to maintaining their health and that of their families. It is NOT intended for those who are anti-vaccine and as such is NOT intended to foster a discussion on the merits of vaccines in this forum. It is also NOT intended to foster a discussion of the lethality of COVID-19 or the need for civic action to limit the spread of the disease.